Dose
Dose is defined as the amount of a substance administered at one time. However, other parameters are needed to characterize the exposure to xenobiotics. The most important parameters are the number of doses, frequency, and total time of the treatment.
For example:
- 650 mg acetaminophen (Tylenol® products) as a single dose
- 500 mg penicillin every 8 hours for 10 days
- 10 mg DDT per day for 90 days
Types of doses include:
- Absorbed dose: the amount of a substance that entered the body through the skin, eyes, lungs, or digestive tract and was taken up by organs or tissues. Absorbed dose can also be called internal dose.
- Administered dose: the quantity usually administered orally or by injection (note that an administered dose taken orally may not necessarily be absorbed).
- Total dose: the sum of all individual doses.
Knowledge Check Choose the best answer for the question.
4-6. "Dose" is defined as _____.
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